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{html} <div style="font-family:Arial, sans-serif; color:#0f172a; margin:0; padding:0;"> <div style="margin:0 auto;"> <header style="margin-bottom:20px;"> <h1 style="margin:0; font-size:1.6rem;">Travel-related Food & Water Pathogens</h1> </header> <div style="background:#ffffff; border-radius:12px; box-shadow:0 6px 18px rgba(16,24,40,0.06); padding:12px;"> <p><span style="display:inline-block; font-size:12px; padding:4px 8px; border-radius:999px; background:#eef2ff; color:#0b3b91; margin-right:6px;">Note</span> This file is meant as a quick reference.</p> <table aria-label="Pathogens grouped" style="width:100%; border-collapse:collapse; margin-top:12px;"> <thead> <tr> <th style="background:#eef2ff; padding:12px; text-align:left; border-bottom:1px solid #e6eef8;">Short-Term (acute, days)</th> <th style="background:#eef2ff; padding:12px; text-align:left; border-bottom:1px solid #e6eef8;">Long-Term / Prolonged (weeks → months)</th> <th style="background:#eef2ff; padding:12px; text-align:left; border-bottom:1px solid #e6eef8;">Dormant / Latent (months → years)</th> </tr> </thead> <tbody> <tr> <td style="padding:12px; vertical-align:top; border-bottom:1px solid #f1f5f9;"> <strong>Bacteria</strong> <ul> <li> Escherichia coli (ETEC, EAEC, EHEC — traveler’s diarrhea; EHEC may cause HUS) <br><small style="color:#374151">Symptoms: watery diarrhea, abdominal cramps; EHEC may cause bloody diarrhea and HUS.<br>Treatment: Oral rehydration; loperamide for symptomatic relief if no fever or bloody stools; antibiotics (azithromycin or rifaximin) for severe traveler’s diarrhea. Avoid antibiotics if EHEC suspected—management is largely supportive and HUS needs hospital care.</small> </li> <li> Salmonella (non-typhoidal) <br><small style="color:#374151">Symptoms: diarrhea (sometimes bloody), fever, abdominal cramps.<br>Treatment: Usually supportive (fluids, electrolytes). Antibiotics (ciprofloxacin, azithromycin, ceftriaxone) reserved for severe disease, bacteremia, or high-risk hosts (infants, elderly, immunocompromised).</small> </li> <li> Shigella <br><small style="color:#374151">Symptoms: high fever, bloody/mucoid diarrhea, tenesmus.<br>Treatment: Rehydration and supportive care; antibiotics (azithromycin or ceftriaxone) recommended for severe cases or to shorten infectivity—choice guided by local resistance patterns.</small> </li> <li> Campylobacter <br><small style="color:#374151">Symptoms: crampy abdominal pain, fever, sometimes bloody diarrhea.<br>Treatment: Supportive care and fluids. Azithromycin is first-line for severe or prolonged cases; early antibiotic therapy shortens duration.</small> </li> <li> Vibrio parahaemolyticus <br><small style="color:#374151">Symptoms: watery diarrhea, abdominal cramps, sometimes vomiting.<br>Treatment: Mostly supportive (rehydration). Antibiotics (doxycycline or azithromycin) for severe infections.</small> </li> <li> Vibrio vulnificus (raw shellfish; severe in liver disease) <br><small style="color:#374151">Symptoms: may cause severe wound infections, rapidly progressive cellulitis, septicemia; fever and blistering skin lesions are common.<br>Treatment: Emergency care—doxycycline plus a third‑generation cephalosporin (e.g., ceftriaxone) or cefotaxime; surgical debridement for wound infections.</small> </li> <li> Yersinia enterocolitica <br><small style="color:#374151">Symptoms: fever, abdominal pain (can mimic appendicitis), diarrhea.<br>Treatment: Usually supportive; antibiotics (fluoroquinolones or third‑generation cephalosporins) for severe or systemic disease.</small> </li> <li> Aeromonas & Plesiomonas <br><small style="color:#374151">Symptoms: watery diarrhea, sometimes bloody; associated with freshwater/seafood exposure.<br>Treatment: Supportive for mild cases; ciprofloxacin or trimethoprim‑sulfamethoxazole for severe illness.</small> </li> </ul> <strong>Toxin-mediated bacteria</strong> <ul> <li> Staphylococcus aureus (preformed toxin — rapid vomiting) <br><small style="color:#374151">Symptoms: abrupt onset of severe vomiting (1–6 hours after ingestion), nausea, sometimes diarrhea.<br>Treatment: Supportive care—oral rehydration, antiemetics; antibiotics are not indicated.</small> </li> <li> Bacillus cereus (emetic & diarrheal types — e.g., fried rice) <br><small style="color:#374151">Symptoms: emetic form—nausea and vomiting within hours; diarrheal form—watery diarrhea and cramps later.<br>Treatment: Supportive (fluids, antiemetics); illness is usually self-limited.</small> </li> <li> Clostridium perfringens (cafeteria/stew outbreaks) <br><small style="color:#374151">Symptoms: abdominal cramps and watery diarrhea 8–16 hours after ingestion.<br>Treatment: Supportive care and hydration; antibiotics rarely needed.</small> </li> </ul> <strong>Viruses</strong> <ul> <li> Norovirus <br><small style="color:#374151">Symptoms: sudden onset vomiting, watery diarrhea, abdominal cramps, low‑grade fever; highly contagious.<br>Treatment: Supportive—oral rehydration, isolation/hygiene to prevent spread.</small> </li> <li> Rotavirus (children) <br><small style="color:#374151">Symptoms: fever, vomiting, watery diarrhea—can cause dehydration in young children.<br>Treatment: Supportive (ORS); vaccine is preventive.</small> </li> </ul> <strong>Marine toxins / Chemicals</strong> <ul> <li> Scombroid (histamine fish poisoning) <br><small style="color:#374151">Symptoms: flushing, headache, palpitations, oral burning, occasionally GI upset shortly after eating spoiled fish.<br>Treatment: Antihistamines (H1 ± H2), supportive care; symptoms usually resolve within hours.</small> </li> <li> Ciguatera <br><small style="color:#374151">Symptoms: GI symptoms followed by neurological complaints (paresthesias, temperature reversal, myalgias); can persist for weeks–months.<br>Treatment: Supportive (fluids, symptomatic relief). Mannitol infusion has been used early in some cases; neuropathic pain medications for persistent symptoms; avoid alcohol and seafood thereafter.</small> </li> <li> Shellfish toxins (paralytic, diarrheic, amnesic) <br><small style="color:#374151">Symptoms: vary by toxin—GI upset to neurological and respiratory compromise.<br>Treatment: Mostly supportive; severe neurotoxic syndromes require intensive care and respiratory support.</small> </li> <li> Food additives, pesticides, heavy metals <br><small style="color:#374151">Symptoms: variable GI and systemic effects depending on agent.<br>Treatment: Supportive and toxin-specific management—seek urgent medical evaluation and toxicology advice.</small> </li> </ul> </td> <td style="padding:12px; vertical-align:top; border-bottom:1px solid #f1f5f9;"> <strong>Bacteria</strong> <ul> <li> Salmonella Typhi / Paratyphi (typhoid fever) <br><small style="color:#374151">Symptoms: prolonged fever, headache, abdominal pain, sometimes constipation or diarrhea, rose spots.<br>Treatment: Antibiotics guided by susceptibility—commonly ceftriaxone (IV for severe) or azithromycin (oral); vaccination is preventive. Chronic carriers may require prolonged antibiotics and sometimes cholecystectomy.</small> </li> <li> Listeria monocytogenes (pregnancy, neonates, immunocompromised) <br><small style="color:#374151">Symptoms: fever, myalgias, GI symptoms; can progress to meningitis or sepsis, dangerous in pregnancy and neonates.<br>Treatment: Ampicillin (often with gentamicin for severe disease); TMP‑SMX for penicillin-allergic patients.</small> </li> <li> Campylobacter (post-infectious GBS, reactive arthritis) <br><small style="color:#374151">Symptoms: see acute Campylobacter (fever, crampy bloody diarrhea); may trigger Guillain–Barré syndrome or reactive arthritis weeks after infection.<br>Treatment: Acute infection—supportive or azithromycin if indicated; complications (GBS, reactive arthritis) require specialist care (neurology/rheumatology) and supportive/immune therapies.</small> </li> <li> Shigella (reactive arthritis) <br><small style="color:#374151">Symptoms: acute dysentery with possible long-term reactive arthritis in susceptible individuals.<br>Treatment: Acute—rehydration and antibiotics (azithromycin/ceftriaxone) when indicated; reactive arthritis managed symptomatically and by specialists.</small> </li> <li> Helicobacter pylori (chronic gastritis/ulcer disease — possible food/water transmission) <br><small style="color:#374151">Symptoms: dyspepsia, epigastric pain, peptic ulcer disease; chronic infection increases gastric cancer risk.<br>Treatment: Eradication therapy—PPI-based triple therapy (PPI + clarithromycin + amoxicillin/metronidazole) or bismuth quadruple therapy depending on local resistance.</small> </li> </ul> <strong>Viruses</strong> <ul> <li> Hepatitis A (acute hepatitis; weeks → months) <br><small style="color:#374151">Symptoms: fever, malaise, anorexia, jaundice, dark urine, abdominal discomfort; illness can last several weeks.<br>Treatment: Supportive care (rest, hydration, avoid hepatotoxins). Vaccine and post-exposure immunoglobulin are preventive/mitigative options.</small> </li> <li> Hepatitis E (can be prolonged or chronic in immunocompromised) <br><small style="color:#374151">Symptoms: similar to hepatitis A; higher risk of fulminant disease in pregnancy and chronic infection in immunocompromised.<br>Treatment: Supportive for acute infection; ribavirin considered for chronic infection in immunocompromised patients (specialist management required).</small> </li> </ul> <strong>Parasites</strong> <ul> <li> Giardia lamblia (chronic/IBS-like symptoms) <br><small style="color:#374151">Symptoms: greasy, foul-smelling stools, bloating, flatulence, abdominal cramps, malabsorption in chronic cases.<br>Treatment: Tinidazole (single dose) or metronidazole; nitazoxanide is an alternative.</small> </li> <li> Cryptosporidium (weeks; longer if immunocompromised) <br><small style="color:#374151">Symptoms: profuse watery diarrhea, cramps, sometimes nausea and low-grade fever.<br>Treatment: Nitazoxanide in immunocompetent hosts; supportive care and immune restoration (e.g., ART in HIV) are central in immunocompromised patients.</small> </li> <li> Cyclospora (waxing/waning diarrhea weeks → months) <br><small style="color:#374151">Symptoms: prolonged, intermittent watery diarrhea, weight loss.<br>Treatment: Trimethoprim–sulfamethoxazole (TMP‑SMX, Bactrim) is the treatment of choice.</small> </li> <li> Entamoeba histolytica (dysentery, liver abscess) <br><small style="color:#374151">Symptoms: bloody diarrhea, abdominal pain; liver abscess presents with fever and right upper quadrant pain.</small> <br><small style="color:#374151">Treatment: Metronidazole or tinidazole for invasive disease followed by a luminal agent (paromomycin or diloxanide) to eradicate cysts and prevent relapse. Drainage may be required for large liver abscesses.</small> </li> <li> Toxoplasma gondii (tissue cysts; reactivation if immunosuppressed) <br><small style="color:#374151">Symptoms: usually asymptomatic or mild lymphadenopathy/flu-like symptoms; severe disease in immunocompromised or congenital infection (neurological/ocular disease).<br>Treatment: For severe or symptomatic infections—pyrimethamine + sulfadiazine + folinic acid; alternatives exist and specialist input is needed for complex cases.</small> </li> </ul> <strong>Marine toxins (long-term sequelae)</strong> <ul> <li> Ciguatera (neurological symptoms can persist) <br><small style="color:#374151">Symptoms and treatment noted under Short-Term marine toxins; neurological symptoms can persist and require symptomatic management and specialist input.</small> </li> </ul> </td> <td style="padding:12px; vertical-align:top; border-bottom:1px solid #f1f5f9;"> <strong>Parasites</strong> <ul> <li> Entamoeba histolytica (silent carriage → later liver abscess/dysentery) <br><small style="color:#374151">Symptoms: may be asymptomatic for long periods or later present with dysentery or liver abscess (fever, RUQ pain).<br>Treatment: Invasive disease—metronidazole or tinidazole followed by luminal agent (paromomycin/diloxanide) to eradicate cysts; asymptomatic carriers treated with luminal agents.</small> </li> <li> Giardia lamblia (intermittent flares) <br><small style="color:#374151">Symptoms and treatment as noted above (tinidazole/metronidazole; nitazoxanide as alternative).</small> </li> <li> Taenia spp. (tapeworms) — intestinal persistence; <em>Taenia solium</em> → neurocysticercosis <br><small style="color:#374151">Symptoms: intestinal infection may be asymptomatic or cause mild GI symptoms; <em>T. solium</em> cysts in the brain cause seizures, headaches, focal deficits years later.<br>Treatment: Intestinal tapeworms—praziquantel or niclosamide. Neurocysticercosis requires specialist management with albendazole (± praziquantel), corticosteroids, and seizure control as indicated.</small> </li> <li> Strongyloides stercoralis (auto-infection; decades-long persistence; severe if immunosuppressed) <br><small style="color:#374151">Symptoms: often asymptomatic; may cause intermittent GI symptoms, cough, or urticarial rashes; hyperinfection in immunosuppressed leads to severe disseminated disease.<br>Treatment: Ivermectin is first-line (dose/duration guided by severity); severe or disseminated infection requires prolonged ivermectin and inpatient care.</small> </li> <li> Plasmodium vivax & ovale (malaria hypnozoites — relapses; travel-related but not foodborne) <br><small style="color:#374151">Symptoms: fever, chills, anemia, systemic symptoms during blood-stage illness; relapses due to dormant liver hypnozoites.<br>Treatment: Treat acute blood-stage infection per regional guidelines (chloroquine or ACTs depending on resistance). Radical cure to prevent relapses—primaquine or tafenoquine after G6PD testing.</small> </li> <li> Toxoplasma gondii (latent tissue cysts) <br><small style="color:#374151">Symptoms and treatment summarized above; latent cysts can reactivate in immunosuppressed patients—specialist care required.</small> </li> </ul> <strong>Bacteria / Chronic Carriage</strong> <ul> <li> Salmonella Typhi (chronic gallbladder carriage) <br><small style="color:#374151">Symptoms: carriers are often asymptomatic but can intermittently shed organisms and transmit infection.<br>Treatment: Prolonged antibiotics guided by susceptibility (historically fluoroquinolones, but resistance is common); cholecystectomy is considered for persistent carriage. Public health follow-up is important.</small> </li> <li> Helicobacter pylori (long-term stomach colonisation) <br><small style="color:#374151">Symptoms and treatment summarized above—eradication therapy with PPI-based regimens or bismuth quadruple therapy based on resistance patterns.</small> </li> </ul> </td> </tr> </tbody> </table> <p style="margin-top:14px; color:#6b7280; font-size:13px;">Legend: This table focuses on food & water–related pathogens and clinically important toxins. It includes regionally important organisms and non-infectious causes that can mimic foodborne illness. Treatments listed are general; local resistance patterns and patient-specific factors (pregnancy, age, immune status, allergies) should guide final therapy—seek clinical/specialist advice when needed.</p> </div> </div> </div> {/html}
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