Cancer Synergies

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The effect of synergy exceeds... {br} {pre} | Rank | Combination | Cancer Targets | Evidence Level | Why It Exceeded Expectations | | ----- | ------------------------------------------ | ---------------------------- | ------------------------------------- | ---------------------------------------------------------------------------------------- | | **1** | **Metformin + Aspirin** | Colorectal, breast, prostate | **Human RCT + epidemiology** | ↓ mTOR + ↓ platelet-mediated metastasis → far greater survival benefit than either alone | | **2** | **Metformin + Doxycycline** | Breast, ovarian, lymphoma | **Human trials (CSC markers)** | Hits *bulk tumor metabolism* + *cancer stem cells* simultaneously | | **3** | **Statin + Aspirin** | Prostate, colorectal | **Human observational + mechanistic** | Mevalonate blockade + anti-metastatic platelet inhibition | | **4** | **Sulforaphane + Curcumin (bioavailable)** | Breast, colon, prostate | **Human biomarkers + animal** | Dual epigenetic + NF-κB suppression; strong CSC suppression | | **5** | **EGCG + Quercetin** | Leukemia, prostate | **Human + animal** | Proteasome inhibition + senolytic pressure | {/pre} {br} {pre} | Rank | Combination | Evidence | Best Use Case | | ----- | ------------------------------------- | ------------------------------- | ------------------------------------- | | **6** | **Berberine + Metformin** (low doses) | Human metabolic + animal cancer | Insulin-driven tumors | | **7** | **Doxycycline + Vitamin C (oral)** | Animal + early human | CSC eradication via redox stress | | **8** | **Sulforaphane + EGCG** | Human biomarker | Epigenetic + angiogenesis suppression | | **9** | **Statin + Metformin** | Human observational | mTOR + Ras pathway tumors | {/pre} {br} {pre} | Combination | Evidence | Comment | | ------------------------ | ----------------- | --------------------------- | | Curcumin + EGCG | In-vitro + animal | Bioavailability critical | | Quercetin + Dasatinib* | Human (senolysis) | Dasatinib not home-friendly | | Melatonin + Chemotherapy | Human | Sleep-immune axis synergy | {/pre} {br} !!!PRACTICAL “HIGH-CONFIDENCE” STACKS ...more is not better, too little is not effective. Ask A.I. on a ideal dose. '''Metabolic + CSC suppression''' * Metformin * Doxycycline * Sulforaphane '''Metastasis-focused''' * Aspirin * Statin * EGCG '''Epigenetic / inflammation''' * Curcumin (phytosome) * Sulforaphane * Quercetin {pre} Combination Strategy Example Compounds Observed Effect Whole Food Blend Broccoli, Turmeric, Pomegranate, Green Tea (Pomi-T) Statistically significant reduction in PSA rise in prostate cancer patients (14.7% vs. 78.5% in placebo) 5. Phytochemical + Phytochemical Resveratrol + Quercetin Superior inhibition of colon cancer and apoptosis induction in rat models compared to single agents 2. Phytochemical + Phytochemical Green Tea Extract + Selenium Greater inhibition of colon tumors in rats than either agent alone 2. Phytochemical + Drug EGCG + Sulindac ~66% reduction in intestinal tumors in APC min mice 2. Phytochemical + Drug Fish Oil + Curcumin Over 72% reduction in tumor volume in a pancreatic cancer model by targeting multiple inflammatory pathways 2. Phytochemical + Phytochemical Garlic + Tomato 72% reduction in aberrant crypt foci in a rat colon cancer model, greater than either alone 2. {/pre}
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