โ๏ธ Efficient Protocol for Waterborne Parasites (Thailand & Vietnam)
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| Day | Drug | Dose | Time(s) to take | Target | Notes |
|---|---|---|---|---|---|
| Day 1 | Albendazole | 400 mg โ single dose | 20:00 (evening) โ take with a fatty meal | Common intestinal helminths (Ascaris, hookworm, Trichuris) | Baseline deworming; avoid if pregnant. Taking with food enhances absorption. |
| Days 2โ4 | Nitazoxanide | 500 mg โ twice daily (total 6 doses) | 08:00 & 20:00 each day (with food) | Giardia, Cryptosporidium, Blastocystis, some Entamoeba | Preferred broad protozoal course; well tolerated. Do not combine with tinidazole simultaneously. |
| Days 5โ6 | Rest / Supportive care | โ | Hydration throughout the day; probiotics morning & evening | Recovery / assess response | Light diet, bottled/boiled water, ORS if loose stools; consider S. boulardii or equivalent probiotic. |
| Day 7 (optional) | Tinidazole (only if persistent symptoms) | 2 g โ single dose | 08:00 (single dose, with food) | Amoebiasis or tinidazole-responsive Giardia | Use only if no improvement after nitazoxanide; avoid alcohol during and 72 h after dose; not for pregnancy. |
โ๏ธ Efficient Protocol for Undercooked Meat or Fish Exposure (Thailand & Vietnam)
| Day | Drug | Dose | Time(s) | Target Parasites | Notes |
|---|---|---|---|---|---|
| Day 1 | Albendazole | 400 mg โ single dose (with fatty meal) | 20:00 | General intestinal worms (*Taenia*, *Ascaris*, *Trichuris*) | Basic deworming foundation. Enhances safety of later praziquantel dose. |
| Days 2โ3 | Praziquantel | 25 mg/kg per dose, three doses per day (total 75 mg/kg/day) ร 2 days | 08:00, 14:00, 20:00 (with meals) | Tapeworms, liver flukes, lung flukes | Do not combine with alcohol. May cause dizziness or nausea. Liver support (hydration, rest). |
| Days 4โ5 | Rest / Recovery | โ | Hydrate and monitor symptoms morning & night | Liver and GI recovery | Bland diet, probiotics, no alcohol, avoid heavy fats. Re-evaluate energy, digestion, and stool. |
| Day 7 | Ivermectin (optional) | 200 ยตg/kg single dose | 08:00 (before breakfast) | Strongyloides, other nematodes | Take on empty stomach; avoid if unconfirmed filarial infection. |
๐ Unified Broad-Spectrum Parasite Treatment Protocol (Thailand & Vietnam)
Covers: Tapeworms, flukes, roundworms, Giardia, amoebae, Cryptosporidium, Strongyloides, Trichinella, and most protozoa.
| Day | Drug | Dose | Time(s) | Targets | Notes |
|---|---|---|---|---|---|
| Day 1 | Albendazole | 400 mg single dose (evening) | 20:00 โ with fatty meal | Roundworms, hookworm, Taenia cyst stage | Foundation dewormer. Precedes praziquantel to reduce cyst activation risk. |
| Days 2โ3 | Nitazoxanide | 500 mg twice daily ร 3 days | 08:00 & 20:00 โ with food | Giardia, Cryptosporidium, amoebae, Blastocystis | Gentle and effective for protozoa; may turn urine yellow-green temporarily. |
| Days 4โ5 | Praziquantel | 25 mg/kg per dose ร 3 doses per day (every 6 hours) | 08:00 / 14:00 / 20:00 โ with meals | Tapeworms, flukes, schistosomes | Take with meals. May cause dizziness or nausea. Hydrate well. |
| Day 7 | Ivermectin (optional) | 200 ยตg/kg single dose | 08:00 โ empty stomach | Strongyloides, cutaneous nematodes | Only if skin rash or soil contact likely. Avoid alcohol for 24 h before/after. |
๐ฎ๐ณ India Specific
| Day | Drug | Dose | Time(s) to take | Primary targets | Notes / next steps |
|---|---|---|---|---|---|
| Day 1 (start) | Albendazole | 400 mg PO โ single dose | 20:00 โ with a fatty meal | STH: *Ascaris*, hookworm, *Trichuris*; partial coverage for tissue worms | Baseline deworming to reduce worm load and aid recovery. Avoid in pregnancy. |
| Days 1โ3 (start immediately) | Nitazoxanide | 500 mg PO twice daily ร 3 days | 08:00 & 20:00 โ with food | Protozoa: *Giardia*, *Cryptosporidium*, *Blastocystis*; some *Entamoeba* | Good first-line for suspected metronidazole-resistant *Giardia/Entamoeba*. Monitor tolerance; urine may darken slightly. |
| Day 4 | Rest / assess | โ | Hydration, light diet, probiotics AM/PM | Recovery & response check | If symptoms improved โ stop and monitor. If persistent/worse โ follow refractory steps below (Day 5+). |
| Day 5 (refractory option) | Tinidazole (or Metronidazole alternative) | Tinidazole 2 g PO once โ OR Metronidazole 500 mg PO TID ร 7 days | 08:00 (single tinidazole dose with food) โ avoid alcohol 72 h | Refractory *Giardia* or *Entamoeba* (amoebic colitis needs clinician confirmation) | If *E. histolytica* suspected clinically, follow tinidazole/metronidazole with a luminal agent (e.g., paromomycin or diloxanide) per clinician. |
| Day 6โ7 (optional) | Ivermectin (only if indicated) | 200 ยตg/kg PO once (may repeat next day if local guidance) | 08:00 โ empty stomach | *Strongyloides* (suspected with eosinophilia, pruritic rash, pulmonary symptoms) | Only use when clinical/epidemiologic suspicion; check for filarial co-endemic risk if relevant. Not for pregnancy. |
| Supportive (Days 1โ14) | Hydration, probiotics, nutrition | Probiotic (e.g., S. boulardii 250 mg) AM & PM; ORS PRN | Morning & evening | Gut recovery, prevent dehydration | Avoid raw/uncertain food & ice; follow up if weight loss continues. |
IMMORTALITY