Cancer Synergies

The effect of synergy exceeds...



Rank  Combination                                Cancer Targets               Evidence Level                        Why It Exceeded Expectations                                                             
 
 
 
 
 
**1** **Metformin + Aspirin**                    Colorectal, breast, prostate **Human RCT + epidemiology**          ↓ mTOR + ↓ platelet-mediated metastasis → far greater survival benefit than either alone 
**2** **Metformin + Doxycycline**                Breast, ovarian, lymphoma    **Human trials (CSC markers)**        Hits *bulk tumor metabolism* + *cancer stem cells* simultaneously                        
**3** **Statin + Aspirin**                       Prostate, colorectal         **Human observational + mechanistic** Mevalonate blockade + anti-metastatic platelet inhibition                                
**4** **Sulforaphane + Curcumin (bioavailable)** Breast, colon, prostate      **Human biomarkers + animal**         Dual epigenetic + NF-κB suppression; strong CSC suppression                              
**5** **EGCG + Quercetin**                       Leukemia, prostate           **Human + animal**                    Proteasome inhibition + senolytic pressure                                               





Rank  Combination                           Evidence                        Best Use Case                         
 
 
 
 
**6** **Berberine + Metformin** (low doses) Human metabolic + animal cancer Insulin-driven tumors                 
**7** **Doxycycline + Vitamin C (oral)**    Animal + early human            CSC eradication via redox stress      
**8** **Sulforaphane + EGCG**               Human biomarker                 Epigenetic + angiogenesis suppression 
**9** **Statin + Metformin**                Human observational             mTOR + Ras pathway tumors             





Combination              Evidence          Comment                     
 
 
 
Curcumin + EGCG          In-vitro + animal Bioavailability critical    
Quercetin + Dasatinib*   Human (senolysis) Dasatinib not home-friendly 
Melatonin + Chemotherapy Human             Sleep-immune axis synergy

PRACTICAL “HIGH-CONFIDENCE” STACKS

...more is not better, too little is not effective. Ask A.I. on a ideal dose.

Metabolic + CSC suppression

  • Metformin
  • Doxycycline
  • Sulforaphane

Metastasis-focused

  • Aspirin
  • Statin
  • EGCG

Epigenetic / inflammation

  • Curcumin (phytosome)
  • Sulforaphane
  • Quercetin



Combination Strategy

	

Example Compounds

	

Observed Effect


Whole Food Blend

	

Broccoli, Turmeric, Pomegranate, Green Tea (Pomi-T)

	

Statistically significant reduction in PSA rise in prostate cancer patients (14.7% vs. 78.5% in placebo) 5.



Phytochemical + Phytochemical

	

Resveratrol + Quercetin

	

Superior inhibition of colon cancer and apoptosis induction in rat models compared to single agents 2.



Phytochemical + Phytochemical

	

Green Tea Extract + Selenium

	

Greater inhibition of colon tumors in rats than either agent alone 2.



Phytochemical + Drug

	

EGCG + Sulindac

	

~66% reduction in intestinal tumors in APC min mice 2.



Phytochemical + Drug

	

Fish Oil + Curcumin

	

Over 72% reduction in tumor volume in a pancreatic cancer model by targeting multiple inflammatory pathways 2.



Phytochemical + Phytochemical

	

Garlic + Tomato

	

72% reduction in aberrant crypt foci in a rat colon cancer model, greater than either alone 2.

  

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